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KMID : 0605720160220010093
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Journal of the Korean Society of Biological Therapies in Psychiatry
2016 Volume.22 No. 1 p.93 ~ p.100
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The Correlations between Cortisol, Dehydroepiandrosterone Sulfate(DHEAS) and Severity of Depressive Symptoms
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Jang Seo-Young
Seo Min-Soo
Woo Jung-Min
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Abstract
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Objectives：Cortisol and dehydroepiandrosterone sulfate(DHEAS) are neuroactive steroids related mood disorder as well as stress response. The purposes of this study are to examine the correlations between cortisol, DHEAS and severity of depressive symptoms and to evaluate the possibility of cortisol and DHEAS as biomarkers for depression.
Methods：A total of 60 participants who had no history of psychiatric disease were recruited. We assessed the severity of depressive symptoms using the Beck Depression Inventory(BDI) and the Hamilton Depression Rating Scale(HAMD). The blood samples were collected between 12 PM to 14 PM. We applied an ELISA to measure the level of cortisol and DHEAS.
Results：The depressive group showed higher cortisol level(Base on BDI : 13.64±7.91 ug/dL, p＜0.001 ; Base on HAMD: 14.14±8.34 ug/dL, p＜0.001). Cortisol level showed positive correlation with the severity of depressive symptoms based on BDI (r=0.572 ; p＜0.01) and HAMD(r=0.638 ; p＜0.01). DHEAS level significantly correlated with BDI score (r=0.398 ; p＜0.01) but not with HAMD score.
Conclusion：These findings suggest that cortisol and DHEAS may have a role as biomarkers for evaluating depression. DHEAS was associated with only one side of two scales. This may suggest the level of steroid hormone is different depending on specific depressive symptoms.
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KEYWORD
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Depression symptoms, Beck depression inventory, Hamilton depression rating scale, Cortisol, DHEAS
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